State estimates for 15 measures of substance use and mental disorders based on the combined 2014 and 2015 National Surveys on Drug Use and Health (NSDUHs) are provided. The NSDUH is an annual survey of the civilian, noninstutionalized population of the United States aged 12 years or older. State and regional estimates are based on a small area estimation (SAE) methodology in which state-level NSDUH data are combined with county and census block group/tract-level data from the state.